I took the final step for this year's sofobomo and made the book available on Blurb. You can check out the listing here:
I used Blurb's PDF to book process which involved setting up a new template in InDesign and re-assembling the book. A couple of important changes from the online sofobomo version included: The layout size was slightly smaller (I will see what impact it has when I receive the printed copy) to fit Blurb's standard landscape size. I also regenerated the JPEG files from Lightroom with different sharpening settings for print vs. screen output. Finally, I used Blurb's pre-set export options for PDF generation which expanded the output resolution to 300dpi.
According to Blurb's literature, their printing system automatically converts SRGB files into the CMYK profile for their HP Indigo printer. Because Lightroom does not handle CMYK profiles directly, I stayed with my standard workflow and exported the JPEG files in SRGB for use in InDesign. I will see how good the color and tone reproduction is with this workflow. If I am unsatisfied with the color, I may run a small test book by exporting the raw image files from from Photoshop as TIFF's using the HP Indigo CMYK output profile on Blurb's site. This may provide better image quality; it all depends how how good Blurb's SRGB to CMYK conversion is. I'll keep you posted on the image quality results.
Another variable that I want to get a handle on is InDesign vs. Booksmart. While they are vastly different layout environments, I do not know if there is an image or typeface quality difference in using them. As my current book is done with InDesign, I'll try a small test with booksmart to see if there is a meaningful difference.